A Cure for Alzheimer’s disease? – CEO of Leucadia Therapeutics Doug Ethell -Learning with Lowell 176

April 14, 2023

Doug Ethell is the founder and CEO of Leucadia Therapeutics, a pre-clinical stage company developing an early diagnostic for Alzheimer’s disease and a therapeutic device to stop that disorder in its earliest stages.

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PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH

RSS: https://www.learningwithlowell.com/feed/podcast/

Twitter: https://twitter.com/LWThompson5

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Website: https://www.learningwithlowell.com

Dough Ethell Links

https://www.leucadiatx.com/aboutus

https://www.linkedin.com/in/dougethell/

Timestamps / Show notes

00:00 Introducing Doug Ethell

00:25 Doug Ethell’s background

03:30 Learning new things

07:30 Faking ignorance in exams 

09:40 Problem solving environment optimization 

11:51 Cold showers, nutrition, and fitness

12:40 Coffee addiction

13:30 Textbooks saying the brain doesn’t repair vs real life

20:20 Growth Cone / axolotls

21:50 Seeing the science 

24:50 Finding a tumor 

25:45 Finding animal models that will translate results into human brains for alzheimer’s research 

28:30 Horror stories of skipping animal models and non animal research FDA

30:15 Choosing data to give FDA and auditing 

31:20 NeuroAge, alzheimer’s drama, and trusting researching 

34:12 Alzhimers drama explained  / amyloid hypothesis 

50:30 Cholesterol / brain combination and Leucadia therapy 

54:12 Progression of Azheimer and filtering CFS

59:16 Utilizing the nose pathway and spinal tap 

01:01:5 Theoretically get the same amount of CFS from nose as from spine

01:02:22 Leucadia device development 

01:04:05 Close / open valve and pacemaker simile 

01:06:30 Animal model downside for research, and researching the effect of nose CFS occlusion

01:10:05 Baseline ferret testing, progression

01:10:40 Timeline for device to market and cost efficient Leucadia plan

01:12:30 Ferrets regaining function and what they monitored

01:13:30 Team member needs

01:14:20 Investors  / Series A

01:15:20 Picking places to do research

01:15:48 Books!

01:17:26 Currently learning / hobbies 

01:18:47 Einsteins weird brain 

01:20:20 PTSD 

01:20:51 Ways to stay up to date with Leucadia ad Doug

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