Dr. Bjorn Schumacher – DNA Repair Mechanisms, Longevity, & DREAM complex – Learning with Lowell 180

April 28, 2023

Dr. Björn Schumacher is the Principal Investigator and Chair for Genome Stability in Ageing and Disease at the Institute for Genome Stability in Aging and Disease. His research group uses the nematode worm Caenorhabditis elegans to understand the causal role of DNA damage in aging and disease.

Over 321 books from 170 plus interviews over 5 years

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The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

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Björn Schumacher 

https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher

Timestamps / chapters

00:00 START!

00:48  Research into DNA repair mechanisms

02:07  Deciding to pursue research 

03:40  Passion in biology

06:40 Tools, tech, and mythology limits for longevity research

10:10 Best data to gather on humans

12:10 Mouth swap and more data

14:00 Blood donation and signing up for research

15:00 Access to the data

17:40 Places leading the world in research

20:35 Immortal germline how and why

24:30 DREAM complex downregulation functions

28:10 Regulating DREAM complex in humans

29:30 Academia to biotech startup transition  

31:30 Timeline to startup

33:35 Humans and DREAM complex
34:40 Typical DNA damage 

37:40 DanThePurple listener question on DDR and DREAM complex

40:15 Extensive of worm lifespan

40:40 Enough_Concentrate21 listener question DNA damage repair in young vs old populations

42:30 Axolotls, whales vs humans for regeneration and aging

45:25 Life expensive and healthspan increase for humans with his research applied to them

48:30 Single or multiple interventions with DNA damage repair

50:15 Capacity of his research

51:15 Help he needs

52:25 SENS and other partnerships

53:38 Amount needed to complete research

54:50 Grant money and research

56:40 100 year projects

57:58 25 to 35 year old advice for getting into longevity 

01:00:10 Bad advice to avoid  

01:02:20 Mark C fan question on AI and ML advances on longevity

01:04:50 Knowledge to save if we had to reset

01:05:30 Udhasudas fan question on radiation dose on humans 

01:09:06 Shocking affect

01:10:50 Miscarriages

01:11:50 Regeneration of germ cells

01:13:15 Books!

01:14:20 Staying up to date with Bjorn’s work   

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