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Matthew and Lowell discussed the development of a new DNA targeting intervention to clear senescent cells. They highlighted the unique approach of Oisin, which targets cells based on their transcriptional activity rather than their appearance or behavior. The conversation also touched on the challenges of DNA delivery, the potential for future adaptations to target new pathways, and the advantages of their non-viral vector. Matthew shared his journey into biotech, developing an app store for the human body, and the shift in the field’s perception of his idea. The conversation ended with a discussion on the potential of using machine learning and control in building therapies that would have been difficult in the past.
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH
RSS: https://www.learningwithlowell.com/feed/podcast/
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Website: https://www.learningwithlowell.com
Matthew Scholz links
Timestamps
01:30 DNA Targeting Intervention for Senescent Cells
10:00 Business Model and Teamwork in Biotech
16:00 Immune System App Store Conceptualization
19:00 Bio App Store Journey: From Skepticism to Acceptance
27:00 Team’s Journey: Overcoming Challenges, Securing Funding
36:00 Seed Rounds in Biotechnology: Simplified and Protective
39:00 Senescent Cell Therapies and Brain Health
47:00 Preclinical to Clinical Challenges and Animal Testing Concerns
53:00 Targeted Biological Research Challenges
57:00 Machine Learning in Therapy Development
1:00:00 Schwarzenegger Mice: Benefits and Risks in Therapy and Metabolic Health
1:10:00 Foundations, Research, and Synthetic Biology
1:15:00 Where He needs help