John Lewis: Metastatic Cancer, Entos Pharmaceutical, Nucleic acid platform |Learning with Lowell 192

June 9, 2023

Dr. Lewis is the Bird Dogs Chair in Translational Oncology at the University of Alberta in Edmonton, Alberta. As a scientist and serial entrepreneur, he pioneered the use of intravital imaging in the in vivo study of tumour cell invasion and metastasis to discover key targets for cancer therapeutics. Dr. Lewis also develops novel nanotechnology, nanoparticle drug delivery technologies, and imaging-based treatments for chronic diseases, such as aging and cancer, as well as for early detection of cancers. Dr. Lewis trained at The Scripps Research Institute and received a Ph.D. in biochemistry from the University of Victoria.

Over 321 books from 170 plus interviews over 5 years

Newsletter sign up (new and exciting developments)

https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b

PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH

RSS: https://www.learningwithlowell.com/feed/podcast/

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Website: https://www.learningwithlowell.com/

John Lewis links

https://www.entospharma.com/about

https://ca.linkedin.com/in/john-lewis-29301614

nanosticsdx.com 

entospharma.com 

Timestamp / show notes 

00:00 Intro

00:52 Multiple companies / Sleep / time management 

02:55 Metastatic cancer treatment 

05:40 Flamide  / cancer

06:45 Michael Levin immortal cancer cells and cancer spreading

08:55 Covid parallel 

09:55 Early detection / improving cancer survivability rates 

12:20 Innovation and great science

15:45 Implementing metastatic research

17:40 FDA organ on a chip / cancer on a chip

19:00 Next generation nucleic acid platform 

21:30 Covid and manhattan project acceleration 

25:00 mRNA vs DNA based vaccine 

27:35 2016 founding of Entos Pharmaceuticals

29:00 FQ barrel_master  Political instability preventing clinical trial and continuing trials 

30:45 Coup stopping clinical trial

31:55  FQ attofreak mitochondrial dysfunction in autoimmune diseases

34:55 Moments when things worked out

36:40 Personal expertise  / superpowers

38:15 Currently learning / delivery platform to cells 

40:14 Defining their platform

41:33 Targeting cancer and biophysics nanoparticles 

43:20 Open source AI, ChatGPT, OpenAI, ML

45:10 Parallels from other companies

46:30 Assessing new technologies to add to business

49:45 Decision making for focus

51:50 End of 2030 to fight cancer

54:10 FDA approval and platform technology

55:15 Corpus of cancers

56:15 Discovering unknown cancers

57:15 FQ barrel_master Oisin’s cancer treatment from trials

58:15 Diverse populations for clinical research

59:45 Hiding cure for cancer

01:00:50 FQ barrel_master Oisin’s tech targets a Thymus or any other organ

01:02:30 FQ barrel_master considered transcribing for the diphtheria toxin

01:03:20 Future vision of companies – IPO, acquisition, etc

01:05:33 Partnerships

01:06:20 Advice for 25-35 year olds

01:07:51 Rare skill sets

01:08:50 Keeping investors happy

01:10:25 Differentiate real vs fake people

01:11:40 Strategy for hiring / question asking 

01:13:50 Books!

01:16:30 DNA vs mRNA vaccine deliverability compared

01:18:50 Open source biotech / technology

01:20:21 Licensing in biotech

01:21:20 Exclusive vs non exclusive 

01:21:55 Unanswered question

01:22:55 Orally bioavailable genetic medicine

01:24:55 Staying up to date with his work

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.