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Andy Lee of Vincere Biosciences. “Our innovative pipeline consists of small molecules designed to boost mitophagy, with the potential to become the first-ever medicines capable of slowing or stopping Parkinson’s disease and other age-related conditions.”
Over 321 books from 170 plus interviews over 5 years
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PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH
RSS: https://www.learningwithlowell.com/feed/podcast/
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Website: https://www.learningwithlowell.com/
Andy Lee Links
https://www.facebook.com/Neuroinitiative/
Timestamps
00:00 Intro
00:13 Bio at AI events, and AI at bio events
02:10 AI at Vincere Biosciences
04:25 Developing inhouse vs open source
05:45 Huggingface / heart of closed systems
06:25 Mark Zuckerberg on Open source ML / AI systems
08:45 OpenAI to ClosedAI / Elon Musk
10:54 Sharing / not sharing the weights
12:00 Mark Zuckerberg / open source benefit
14:30 What is Huggingface / where he goes
17:30 ChatGPT, Huggingface, Nvidia GPUs, developing on laptop
19:00 Vincere Biosciences Building on prem or cloud computing
20:50 Security and building your own system
22:30 Crypto compute translate to AI compute
24:30 Gold Mining
25:15 Vincere Biosciences explained
27:40 Mice study results
30:10 Therapeutic index / Mitochondria / Basil mitophagy
32:45 Teaser for results / significance of their research / Parkinson’s disease
35:00 Healthspan / longevity
38:31 Degrading at different rates
39:20 Increasing vs decreasing levels
41:50 Expect of effect on Parkinson’s / Michael J. Fox
44:30 Helping everyone
46:20 Shot, pill, often of taking
46:50 Age of onset of Parkinsons
48:40 Taking for life
49:55 Standing in the way of clinical trials / how long until someone can use it
54:50 Sticking with it / Rare disease / orphan disease
57:55 Michael J. Fox foundation
01:01:16 Biobanking, data sharing
01:02:11 Michael J. Fox foundation data lake / 2030s
01:04:20 Learning from other failures
01:06:40 Book recommendations / Creative Act
01:12:15 Toxic consequence of boosting mitophagy / Salt and pepper fanQ
01:13:55 Fast tracking phase 1 to phase 2 drug / Fan Q
01:19:40 Staying up to date with Vincere Biosciences