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Aubrey De Grey discusses the progress and potential of therapies related to his ideas on anti-aging medicine, including the four therapies that will be tested in a mouse rejuvenation trial. He also shares his thoughts on partnering with organizations and individuals in the field, integrating AI into his work, and the importance of structure in maximizing impact. Aubrey De Grey discusses the potential for Yamanaka factors to be used in organ rejuvenation, and the role of transcription factors in creating induced pluripotent stem cells. He also provides advice for those interested in getting involved in the field and shares his views on time management and productivity. Aubrey De Grey discusses the potential for reversing the pathology of aging to address mechanical issues and mentions promising research being conducted by MAIA Biotechnology on cancerous cells that express telomerase. He also expresses his optimism about the possibility of reaching “longevity escape velocity” within the next 15 years.
Youtube:
Aubrey De Grey links
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074
Twitter: https://twitter.com/LWThompson5
Website: https://www.learningwithlowell.com/
Podcast email: lowell@learningwithlowell.com
Timestamps
00:00 Start
01:00 Mark Hamaleinen write in question: Why we still don’t have any therapies based on his ideas published 20 years ago in his breakout paper
04:30 update on escape velocity. 50% in 15 years.
08:30 Experiments on mice
12:00 Yamanaka factor thoughts, current research on mice continued
14:30 Lev foundation research expanded and explained
16:30 Lev foundation thesis compared to others
21:00 Hardships being at the tip of the innovation field of longevity
23:45 Open source, non profits, lev foundation
26:00 Ideas from previous organizations (ie. SENS) applied in LEV
27:15 Ichor therapeutics, and partnership process of LEV
29:30 Next generation mentorship
30:30 Summer internship program
32:45 Bullish on longevity
33:30 AI role in longevity
35:55 Anything fundamental making longevity therapies only for the rich
38:30 Longevity surgery therapies
39:30 Advice for people
40:30 Bottlenecks of longevity
42:00 Books!
43:05 Staying on cutting edge/ learning
44:15 Current curiosity and fascination
46:45 What happiness means to him and how he optimizes for it
48:30 how he stays healthy over the years, longevity practices he uses
51:45 How much money does he and the space need
52:55 Anything stopping him from getting Jeff Bezos and other high network people to invest or donate
51:55 Thoughts on altos labs & calico labs
56:35 up and coming people that inspire him (crypto people, michael levin)
59:00 Finding up and coming people to work with and for (advice)
60:30 Things people get wrong and what people ask him about longevity
1:01:35 Aubrey newsletter and updates ( news suggestions)
1:03:30 Question he wonders about that doesn’t have answer to
1:04:15 How he maximizes his day and stays productive
1:05:15 Thoughts on MAIA Biotechnology, telomerase, short vs long
1:09:30 Final thoughts on lev foundation.