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Everything you wanted to know about longevity, cholesterol, aging, and the brain and heart connection, but were afraid to ask.
About Oki
“Dr. O’Connor was awarded his master’s degree in neuroscience from Northwestern Medical in 1999 and his Ph.D. in Biochemistry from Baylor College of Medicine in 2005. His postdoctoral research includes work at UC Berkeley on muscle stem cells and aging. He is the former VP of Research at SENS Research Foundation where he oversaw a broad swath of research projects spanning many aspects of rejuvenation biotechnology from which he authored many papers and patents.”
Specialties: Aging research, cyclodextrin, oxidized cholesterol, mitochondria, telomeres, IND enabling drug dev.
Links
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074
Twitter: https://twitter.com/LWThompson5
Website: https://www.learningwithlowell.com/
Podcast email: lowell@learningwithlowell.com
Timestamps
00:00 Start of interview with Dr. Matthew ‘Oki’ O’Connor
00:50 Alzhiemers Gene
02:40 Data cholesterol & Alzhiemers rates
04:20 Aging therapy that affects multiple illnesses
10:20 Team needs to execute at Cyclarity Therapeutics
14:20 Keep longevity team rowing in same direction at Cyclarity Therapeutics
17:00 His role in meetings
19:20 Oxidized Cholesterol types
23:30 Bad types of oxidized cholesterol and the effects it has on the cell
25:20 Level changes of oxidized cholesterol with age
27:10 How body handles oxidized cholesterol
28:00 Size of issue
32.30 Cyclarity Therapeutics’s therapy custom-engineered cyclodextrins and it’s effects on oxidized cholesterol
34:00 Custom-engineered cyclodextrins administration (Cyclarity Therapeutics therapy)
35:00 Future administration thoughts
36:00 Regulatory fun
39:00 What’s left before clinical trials next year?
40:20 Prepared him to lead Cyclarity Therapeutics
43:00 Imposter Syndrome
47:00 Dream of saving billions of lives
49:00 Scaling/Executing – changes in going from concept, to clinical trials, to production
54:00 Where custom-engineered cyclodextrins are made
56:00 Scientists know no boundaries
58:00 Vertical/Horizontal integration
59:20 Books and resources from Dr. Matthew ‘Oki’ O’Connor
1:02:00 My recommendations to him
1:02:20 Advice for people wanting to get into longevity
1:05:20 Personal longevity practices
1:07:20 Things people get caught up on
1:09:20 Stem cells
1:12:00 Staying on cutting edge
1:15:20 How to stay up to date with Dr. Matthew ‘Oki’ O’Connor, Cyclarity Therapeutics, and their development of Custom-engineered cyclodextrins