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Dr. Amit Sharma was awarded a Master’s degree in Biomedical Sciences from Delhi University, India. He received his PhD in 2009 in Biotechnology from University of Pune for his work demonstrating microRNA regulation of cytokines invovled in allergic inflammation in mice models. Dr. Sharma’s postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models.
Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence affects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with translational focus.
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PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
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Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Website: https://www.learningwithlowell.com/
Amit Sharma Links
https://www.sens.org/about-us/team/
https://youtu.be/AoRb1Z0XanM
https://www.sens.org/our-research/
https://www.linkedin.com/in/amit-sharma-1613b189/
Timestamps
00:00 Dr. Amit Sharma
00:45 Which path to achieve longevity/ healthspan
02:40 integrated approach
03:50 Typical week working on longevity
07:20 Black swan events / SENS foundation
08:30 Too high risk ideas
09:09 Innovation brain / Elon Musk
10:50 Dyslexia thinking in 3d and how Amit thinks
12:40 Seeing opportunities
14:20 Amit Sharma Leadership style
16:00 Spinning off companies vs staying in pure research
18:30 Mentorship, life events, inspiration and seeing longevity as the path for her
21:00 Skills to be successful in longevity
24:55 Project / moments at SENS that is awesome
27:15 Longevity and Iron
30:17 Visualizing senescence apoptosis
32:30 Other uses / Cancer applications / USF
34:40 Immune system not aware of eyes
35:52 Blood brain barrier degradation with ate, NK cells, t cells
36:47 T -cells, inflammation, and alzheimer’s
38:44 Crazy ideas for treating alzheimer’s disease
40:40 Cost to build an Amit Sharma center of research within SENS / Idea for Lisa
43:00 Donating money to SENS / mito mouse
45:00 Ancient infections hiding in genome
47:35 Gut microbiome longevity Drosophila
52:25 Mice / research / history of work
56:30 Cell culture, senescence, mouse models creating new perspectives
57:40 FanQ How do you know that the allogeneic CAR-NK cells won’t cause Graft vs Host disease?
1:00:01 FANQ How many possible senescent cell markers do you think there may be in senescent cells? Do you see being able to target say 70% of Senescent cells with just say 10 markers?
1:03:50 FANQ How far do you think you are from an IND application?
1:05:55 FANQ Do you have an orphan indication you might want to target first?
1:06:50 Book recommendations
1:10:00 Amit on never retiring
1:10:30 What he needs help with